Advair vs Spiriva fewer COPD deaths
Dec 29, 2007
No fewer COPD attacks, but fewer deaths with advair than spiriva.
Severe COPD patients treated with Advair or Spiriva had the same rate of COPD attacks, but Advair patients were only half as likely to die.
The finding comes from a head-to-head study pitting Advair against Spiriva in the treatment of patients with very serious chronic obstructive pulmonary disease (COPD).
Does that mean Advair is the best treatment? Not necessarily. The study was primarily designed to see whether one of the COPD treatments cut disease exacerbations -occasional attacks. Both treatments were equally effective in preventing COPD attacks.
Overall, 39% of the patients did not have a COPD exacerbation during the two-year study.
Nevertheless, even though this difference was statistically significant, the study was not large enough to prove that patients on Advair are less likely to die than are patients on Spiriva.
There were other differences as well. Patients assigned to Spiriva treatment were 29% more likely to drop out of the study. Fewer patients assigned to Advair needed oral steroid treatment, but fewer patients assigned to Spiriva needed antibiotic treatment.
"This provides indirect evidence that these treatments affect apparently similar patients in different way”. The international study enrolled 1,323 patients with severe and very severe COPD. Their average age was 64. Different effects of Advair and Spiriva may mean that different drugs may be the best treatment choice for different patients. They recommend further studies to identify factors that may influence the best choice between these two effective COPD drugs.
Source: webmd.com
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